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Local Content Introduction and Types of Depression Related Disorders / Conditions Historical and Current Understandings Biology, Psychology and Sociology Treatment - Medication and Psychotherapy Alternative Medicine and Self-Help Resources Special Issues References More Information A Discussion of Psychotherapy A Discussion of Self Hatred Aging and Depression An Interview with Daniel Strunk, Ph.D., on Cognitive Therapy for Depression Antidepressants No Better Than Placebo Says A New Study, But It's Really More Complicated Than That... Blunt Instruments Brain Neuroplasticity and Treatment Resistant Depression Coming Out of the Depression Closet Cosmo Magic to Cyclothymic: Highs, Lows and States of Flow Depression and Cancer Depression and Diabetes Depression and Heart Disease Depression and HIV/AIDS Depression and Parkinsons Depression and Relationships: The Good News About Feeling Bad Depression and Stroke Depression and the Elusiveness of Pleasure Depression and Women Depression, ADHD, Psychotherapy and Medication Depression, Anxiety and Pets Depression? Stress? How Sweet they Are? A Dissertation on Dark Chocolate Do You Like Me? Setting Limits Dysthymic Disorder Symptoms Elliott Smith and the gift of Vulnerability Music Existential Crisis? Feeling Good, It's Not Just In the Brain Going Postal: The Road to Depression and Salvation Guest Editorial: Celeb Feud Brought Up Critical Issues Helping Children Understand and Cope with Parental Depression Listening to Readers on Prozac, Depression & the Medical System: Part I Listening to Readers on Prozac, Depression & the Medical System: Part II Major Depression Symptoms Men and Depression Men, Face It, There is Male Post Partum Depression National Depression Screening Day, Thursday October 8, 2009 Of Troubled Marriages, Sexual Compulsions and Depression Older Adults: Depression and Suicide Facts Organizations Post Partum Adoption Depression Post Partum Depression and The Importance of Sleep Psychological Impact of Protracted Unemployment Reader Feedback on the Depression Series Running On Fifty Score Another One for Cognitive Therapy Self Compassion Sensory Defensiveness or Sensory Overload St. John's Wort FAQ Students and College, A Stressful Time of Life: Parents and Students Beware Surgery, Depression, and Anxiety Symptoms of Depressive Disorders The Best Anti Depressant is Free! The Biochemical - Psychosexual Revolution: Getting Up and Close while Being Down and Out The Existential Crisis, Depression, Anxiety and Mortality The Five Senses The Liberating and Entangling Webs of Technology, Depression and Prozac The Long Term Effects of Bullying The Physical Symptoms of Depression Top Twelve Tips for Beating (Mostly) Moderate Chronic Clinical Depression Treatment Treatment 1 of 2 Treatment 2 of 2 Unmasking Mental Illness Websites What about the "milder" depression: Dysthymic disorder? Why People Might Use Anxiety to Avoid Depression: Part 2 Why People Might Use Anxiety to Avoid Depression: What We Can Learn From a Wartime Experience Wise Counsel Interview Transcript: An Interview with James Gordon MD on Mind Body Medicine and His Book 'Unstuck' Wise Counsel Interview Transcript: An Interview with with Ronald Dworkin, MD, Ph.D. on Artificial Happiness Woe Is Me, The Self Fulfilling Prophecy Tests Latest News Depression in Mid-Life Linked to Higher Odds for Later Dementia Use of Ecstasy, Speed by Teens Tied to Later Depression Depressed Moms May Hinder Babies' Sleep Chronic Depression Patients Pick Acupuncture Over Counseling Newer Antidepressants May Be Safe for Parkinson's Patients FDA Adds More Warnings to Antidepressant's Label Talking About Weight Tied to Poor Self-Image, Depression: Study Living Alone Linked to Greater Risk of Depression: Study Antidepressants May Raise Risk for Pregnancy Complication Study Explains How Shock Therapy Might Ease Severe Depression First Generic Lexapro Approved Mothers on Antidepressants Less Likely to Breast-Feed: Study Moms' Antidepressants May Affect Babies' Head Size: Study Depression Could Worsen Mental Decline in Heart Patients Dad's Depression May Rub Off on Child's Behavior Migraines May Raise a Woman's Odds of Depression Depressed Kids May Be Targets for Bullying, Study Suggests Fluoxetine, Venlafaxine Tied to Drop in Adult Suicide Behaviors New Assay IDs Individuals With Major Depressive Disorder Could a Blood Test Help Spot Depression? Winter Doldrums Got You Down? Here's How to Bounce Back Antidepressants While Pregnant Linked to Slight Risk of Lung Problem in Babies Deep Brain Stimulation Found Effective for Severe Depression With Depression, Helping Others May in Turn Help You Racial Disparities Seem to Persist in Depression Diagnosis Holiday Blues May Signal Depression Best Antidepressant May Depend on Patient: Study Mom-to-Be's Mental State May Affect Child's Development When Dads Have Depression, Kids May Be at Risk, Too Antidepressant Use Skyrocketed in Past 20 Years: CDC Caffeinated Coffee Reduces Women's Depression Risk Fear of Antidepressants Keep Many From Disclosing Depression Antidepressant Tied to Dangerous Heart Rhythm: FDA Abuse, Neglect in Childhood Linked to Depression in Adulthood Moms' Depression Affects Kids' Brain Structure, Scans Show Depressed Women Could Face Raised Risk of Stroke Americans' Use of Antidepressants On the Rise: Study Specific Criteria Beat DSM-IV in ID of Bipolar in Major Depression Popular Antidepressants Not Always Best Choice for Seniors Childhood Depression, Anxiety Tied to Pain in Adulthood Major Depression Strongly Linked to Social Conditions Depression Higher in Wealthier Nations Kids of Moms With History of Depression Seem Less Happy Prior Depression Can Leave People Sensitive to Life's Woes First Trimester Antidepressant Use Tied to Childhood ASD City Living Tied to More Anxiety, Mood Disorders Recurrent Maternal Depression May Affect Child's Behavior Depressed People Find It Hard to Stop Reliving Bad Times Cognitive Therapy Helps Depressed Drug Abusers REMIT Useful for Evaluating Depression Remission Questions and Answers In Love With a Man Who Does Not Love Me I Think I Have a Mental Disorder? Stress and Loss of Feeling or Emotional Deadness Please Help Me OCD or Not OCD, That's The Question How Can I Move Past This- A Question for Staff Does Romance Lead to Aggression? Am I Depressed? Depressed, Anxious and Dead Inside...Please Help! Broken Why do I Feel Like Everyone is Trying to Upset me? My Husbands Roller Coaster of Proper Hygiene: Is it Depression? I Feel Like a Complete Waste of a Human Life Am I Always Going to Feel Like This? Is He Changed??? I Can't Stop Crying Hopeless Anxious and Depressed Son Is There Any Hope For Me, or am I Destined to be Damaged? Falling Apart Is There Such a Thing as Happiness? Joyless Worrying Too Much About Anything. Helping and Watching a Friend's Recurrent Depression? Homesick and Feeling Stuck. Insanely Jealous Husband POCD Alcohol, No Sex, No Intimacy...Why Am I Here? Can Prescription Drug Use Lead to Delusional Beharior? Social Anxiety, Depression and More... Sad Same Views On So Much, but Can't Get Along As A Couple No Sex Drive - Ever Suicidal Thoughts Hypothyroid 23 Year Old Girl It's Me or It's My Mother? Is He a Narcissist? Help For Aging Human Service Professionals? Depression If There's Nothing New, There's Nothing Good. Please Respond, I Need Help Need To Ask Someone Is it Okay to Give Up? I'm Cheated By My Girlfriend..... I Just Want to Die..... How Can It Help? Everyone Says He is depressed, Is He? Or Does He Really Want a Divorce?? Help! Please! I Think I Need Some Help I Feel So Lost. Scared and Lonely Please Help Me Out How Much Should a Therapist Care or Reach Out? I Never Experience Happiness Mystery Symptoms I Think I'm Depressed Born to Lose, or Nurtured to Lose? Help! Quadruple Bypass Surgery Advice I am an 18 Year Old Mom Diagnosed With Severe Depression And Anxiety Extremely Scared: I Felt Indifferent Toward an Obsession Suffering with Treatment-Resistant Depression My Fiance May Have a Sexual, Nude Photo Addiction Infections and The Brain My Girlfriend's Family Is Ruining Our Relationship Worthless I Need Help And Am At The End of My Rope How Can I Cope With My Husband´s Depression and Its Sexual Consequences? What Is The Difference Between Mental Illness and Depression? Is There Hope For Me? Am I Over Thinking This, or Am I Right? Anger Do I Need Help? What Is It? Why Am I Thinking Like This? Why Does My Mother Hoard Everything, Including Garbage? Right in the middle of a nervous breakdown; What's wrong with me? Huge Disapointment With My Husband I Don't Really Care About Anything. What Should I Do? No Sex Is Post Traumatic Stress Disorder Curable? Is it Really a Problem? I am Terrified of Death. Anhedonia Detached: I Feel Guilty, But I Can't Help it. My Father, The Sociopath... I Feel Like a Question Mark Am I Not Normal!? Our 23 Year Old Son Refuses to Get Help for His Anxiety Attacks and Depression. What is Wrong? Husband Abandoned Me D.I.D. Diagnosis, How do I Accept This? I Don't Know Anymore. Please Help. I Think I am Gay and I Need Help to Convert to Heterosexual? Breaking up With Bipolar Depression - Blacking Out He's Distant. Is he Leaving me? My Boyfriend Saved Pictures of his Ex-Girlfriend on His Computer. Restroom Phobia What Is Wrong with Me? Should I Seek Help? When to Leave Therapy? Help Me Please. What is Going On With Me? I'm Afraid I'm Going Crazy I Don't Know What To Do Am I Wallowing in Depression? Anger Sexual Abuse and Its Effects on Relationships Afterwards What Is Wrong with Me, Doc? Help DBS Am I Suffering a Kind of Psychological Problem? Attention Deficit and Depression Do I Have an Eating Disorder? Do you think I sound depressed? I don't understand what is going on No Sex Drive Is This Bi Polar? Depressed 19 year old college student Thoughts Depression helps to contribute to my unemployment! - Paula Will I ever feel normal? I feel like I am going crazy What is wrong with me? I'm Scared What Is Wrong with Me? Cyclical Depression Frightening thoughts - fear losing control - please help! Anxious, depressed, confused, angry....the typical... My depressed husband won't sleep with me. What should I do? Giving Up - Dad of three - Sep 15th 2008 Counting ritual - Zami - Aug 30th 2008 dont understand me Exercising violence in dreams Swallowing fear My husband wants to leave me Is there help for a person who has always been a 'little depressed' Depression Treatment Please help. Lovely, however... - Julie C. - Jul 14th 2008 I am really worried about my mental health (19yr old female) Am I depressed? Identity Confusion: I don't know what personality disorders I have Do I Have Bipolar Dsorder? Is there something wrong with me? Will I Ever? Worried about my son Is There Help Out There? Lonely Mother of Three Am I Depressed? Help? Major Depressive Disorder Severe with Psychotic Features OCD- No feeling Help!!!: Laci Is the memory of my father dooming my relationship? Worried about thoughts How long will i be on medication for treatment of my depression My Mother Won't Go For Depression Treatment! Where do i start to get on the road to recovery What is wrong with me? Stuck in an on-again, off-again relationship for 10 years Depression Treatment How do I get my dr.s to understand and help me? STUCK IN A RUT What treatments are available after you've tried the medicines of last resort? no one will help! Should I seek help? A fighting couple Do I have a mental health problem? Whats wrong with me? depression and employment how do you treat depression in teenager males? Is it ok to feel this way? Have DID: Getting Worse Not Better Can we contact my mother's doctor? anxiety or going crazy? ADD, Tourettes or both? Depressed I think i'm lost? Don't want to take meds Will this ever end Get Supported Stages of Depression Is there any help? Can you help? Dark Fantasies Blood tests Is it illusion or truth? should a depressed person marry? Dementia and Depression Anger? What type of exams can proven that a person has bipolar disorder? Stuck in a mental rut... Loss of Patience i can't seem to get over any of this Intrusive humiliating memories Is there some way to deal with depression without meds? losing personality wholness What is the point of life? No change is normal mood (e.g., Depression) Lack of Personal Hygiene Diagnosing Depression Does untreated depression pass on to a fetus? A Request for Help Regular thoughts of killing myself How do I help my depressed, unemployed mother Angry at my doctor for prescribing so carelessly I become very hostile towards myself Coming to Terms With My Own Pathetic Existence Do environmental factors hold a person back? Tired of this Depression Struggling With Feelings And Thoughts Greatly Depressed Is Depression Getting More Prevalent? An Empty Shell Helping My Husband Inability To Express Myself Non-medication Help For Depression Suicidal Sick Of Feeling This Way Untrusting Patient Depressed and Not Dating Congenital Laziness Moody Boyfriend Electroconvulsive Therapy Desperate Frustrated and Sucked Dry Too Young For Meds Depressed Husband Paranoid Depression Self-Harming Attention Seeker Did My Parents Make Me Like This? Wild Mood Swings A Wonderful Man How Can I Become Less Depressed? 18, Sad and Hopeless Should I Continue With Therapy? Childhood Depression Can I Help My Wife With Depression? Prozac Questions Approaching My Tightly Wound Depressed Attorney Brother Brain Injury and Depression No Compassion For Depression Recurrent Depression Meds Don't Seem To Work So Now What? Pleasure-blind Do People Recover From Depression? Shy Dancer Crying Is Behavior Med Consult Feeling Depressed and Insecure Shyness And The Post Partum Blues The Aftermath of Abuse Do I Tell My Children I'm Depressed? Now What? Medicine Doesn't Work Anymore Depressed The First Time Depressed Boyfriend How Do I Leave? Potentially Suicidal Boyfriend Alternative Treatment Bereavement and Grief Paranoid Dad Depression Affects The Entire Family How Can I Stop Depression From Recurring? Crohn's Disorder Side Effects Is Paranoia A Destiny? Post-Drinking Depression Security Clearance and Depression Can I Inherit Depression? Two Clinicians Depressed Spouse Depression 101 Hypnosis? Controlling, Disabled Husband Are These Just Mood Swings Drifting Apart? Drinking. . . A Mother Struggles with Depression Marijuana and Depression Overburdened Mom Trashed House Beautiful Dreamer PMS Woes Severely Depressed Miss Lonely Unhappy and In Therapy He Won't Tell Me Why... Lonely Depression Affecting My Relationship Lonesome My Children Aren't Speaking.. My Wife is Depressed My Boyfriend Is Depressed Carolyn writes: Parlante writes: Videos Links Book Reviews Self-Help Groups
New Assay IDs Individuals With Major Depressive Disorder
FRIDAY, Feb. 3 (HealthDay News) -- A multi-assay, serum-based test can be used to distinguish individuals with major depressive disorder (MDD) from controls, with high specificity and sensitivity, according to a study published online Dec. 13 in Molecular Psychiatry .
George I. Papakostas, M.D., from the Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues investigated the diagnostic performance of a multi-assay, serum-based test in patients with MDD. Serum levels of nine biomarkers in peripheral blood were compared in a pilot study involving 36 patients with MDD and 43 non-depressed controls. Results were replicated in a cohort of 34 patients with MDD. Biomarkers were selected on the basis of previous exploratory analyses. A positive test, indicating presence of MDD, was defined as a score of 50 or greater.
In the pilot study, the researchers found that the assay had a sensitivity of 91.7 percent and a specificity of 81.3 percent for differentiation of patients with MDD from controls. In the replication study, sensitivity and specificity were 91.1 and 81.0 percent, respectively.
"The results of the present study suggest that this test can differentiate MDD subjects from non-depressed controls with adequate sensitivity and specificity. Further research is needed to confirm the performance of the test across various age and ethnic groups, and in different clinical settings," the authors write.
Several authors disclosed financial ties to pharmaceutical and biotechnology companies, including Ridge Diagnostics, which funded the study and developed the diagnostic assay tested in the study.
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